Doping Gd3+ Ion in PDA-PHBV Coating on Ti6Al4V Alloy for Enhancing Corrosion Resistance and Proliferation of Human Gingival Fibroblasts and Human Umbilical Vein Endothelial Cells

In this study, we fabricated poly(3-hydroxybutyrate-3-hydroxyvalerate) (PHBV) coatings doped with Gd3+ (1, 5, and 10 × 10−4 mol/L) on Ti6Al4V alloy for the first time to promote soft tissue sealing around dental implants. The corrosion resistance of Gd3+-modified PHBV-coated was studied by electrochemical immersion tests, respectively, whereas CCK-8 RT-PCR evaluated biocompatibility human gingival fibroblasts (HGFs) umbilical vein endothelial cells (HUVECs). It found that PHBV coating could enhance Ti6Al4V. vitro cell tests showed without addition adhesion proliferation HGFs HUVECs, showing a content-dependent manner. Moreover, it PDA-PHBV@1Gd best up-regulating gene expressions VINCULIN, ITGB1, ITGA3, response HUVECs highest expression eNOS HIF-1α genes in PDA-PHBV@5Gd-coated group.